[Nphe1]Nociceptin(1-13)NH2( —— )

Catalog No. M30624 CAS No. 267234-08-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

[Nphe1]Nociceptin(1-13)NH2
Note

Research use only, not for human use.
Brief Description

Selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo.
Description

Selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo.
In Vitro

[Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors expressed in Chinese hamster ovary (CHO) cells (pKi=8.4) and competitively antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0).
In Vivo

——
Synonyms

——
Pathway

Endocrinology/Hormones
Target

Opioid Receptor
Recptor

——
Research Area

——
Indication

——

CAS Number

267234-08-2
Formula Weight

1381.6
Molecular Formula

C61H100N22O15
Purity

>98% (HPLC)
Solubility

10% acetonitrile:1 mg/mL
SMILES

[H]N(CC(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O)CC1=CC=CC=C1
Chemical Name

——

1. Calo et al (2000) Characterization of [Nphe1]nociceptin(1-13)NH2, a new selective nociceptin receptor antagonist. Br.J.Pharmacol. 129 1183 PMID:

Calculator

molnova catalog